
The strike hit the Dandey Darpa Khel area, about five kilometres (three miles) from Miranshah, the main town in North Waziristan district, a known hub for Taliban and Al-Qaeda linked militants.
The area is also famous as stronghold of the Al-Qaeda-linked Haqqani network, known for staging attacks on US and NATO troops fighting in Afghanistan.
"The US drone fired three missiles and hit a house used by militants. Five militants have been killed," A senior security official at Peshawar told AFP.
An intelligence official in Miranshah also confirmed the attack and the toll.